| |
 Quality
controls
Study
of polymorphism
Analysis
of interaction between active substance and other compounds
Consulting
Literature
search
|
|
Quality
control
|
Quality controls
Spectral and thermal analyses of active substances :
| Thermal Methods |
Spectral Methods |
Other Methods |
Differential
Scanning
Calorimetry
(DSC) |
X-Ray Diffraction (XRPD)
|
DVS
(Dynamic Vapor Sorption) |
| Modulated DSC |
Hot-stage X-ray
diffraction
analysis |
pH, pKa, Log P |
Thermogravimetry (TGA)
|
Infrared Spectroscopy (FTIR) |
Water determination
by
Karl Fischer titration |
High resolution TGA
|
Raman Spectroscopy (RS) |
Elemental analysys |
Thermomicroscopy (TM)
|
1H NMR, 13C NMR,
Solid-State NMR |
Optical Rotatory Power |
| TGA / FTIR |
Mass Spectrometry (MS) |
Water content
(Karl Fischer titration) |
| TGA / GC / MS |
HPLC LC/MS LC/MS/MS |
Granulometric measurements |
| Microcalorimetry, VP-DSC, ITC |
X-Ray crystallography-powder
and single crystal |
Specific Area (BET) |
|
|
Drug
polymorphism
|
 Study
of solid forms (polymorphs,
hydrates, solvates and amorphous forms)
Screening of drug solid forms at each stage
of its development and production :
- Identification
- Characterization
- Control
- Crystallization in different solvents
|
|
innovative
analyses
|
 Analysis
of interactions between
active substance and other compounds
(excipients or others)
- By experimental means : phase diagrams
using methods of thermal and spectral analysis
- By theoretical means : computer-assisted
modelling of phase diagrams thanks to the
development of dedicated software
The innovative nature of these analyses resides
in the development of a computer program at the
Faculty of Pharmacy laboratory used to model
interactions between the active substance and
different compounds. By modelling in this way, the manufacturer
can choose the excipient best adapted to the active substance,
i.e. that which optimizes the efficacy of the drug by increasing its bioavailability.
|
|
Advices
for the
manufacturer
|
Consulting
Advices for the manufacturer concerning :
- Powders characterization
- Drug polymorphism
- Aanalysis of interactions between drug substance and other compounds
|
|
For the most
up to date
information
|
Literature search
The laboratory performs regular literature searches for :
- Powders characterization
- Drug polymorphism
- Analysis of interactions between drug substance and other compounds
|
